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Search Results for " alk 5 "
Targets Recommended: ALK

24

抑制剂 & 化合物

17

重组蛋白

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Cat. No. Product Name Target Signaling Pathways
T10283 ALK-IN-5

ALK Angiogenesis; Tyrosine Kinase/Adaptors
ALK-IN-5 is a potent, selective, and brain-penetrant inhibitor of anaplastic lymphoma kinase (ALK, IC50: 2.9 nM).
T3031 A 83-01

ALK5 Inhibitor IV,A8301

 ALK; TGF-beta/Smad Angiogenesis; Stem Cells; Tyrosine Kinase/Adaptors
A 83-01 (ALK5 Inhibitor IV) 是一种 TGF-βI 型受体 ALK5、ALK4 和 ALK7 的抑制剂 (IC50=12/45/7.5 nM)。A 83-01 可促进小鼠成纤维细胞重编程为 iPSCs。A 83-01 可用于类器官培养。
T22560 ALK5 Inhibitor II (hydrochloride)

Others Others
ALK5 Inhibitor II is an ALK5 inhibitor. IC50: 4, 18, and 23 nM for ALK5 autophosphorylation, TGF-β cellular assay, and ALK5 binding in HepG2 cells, respectively.
T67699L ALK/ROS1 inhibitor 2e HCL

(R)-1-(2-((2-methoxy-4-(piperazin-1-yl)phenyl)amino)pyridin-4-yl)-N-(4-(trifluoromethoxy)benzyl)piperidine-3-carboxamide hydrochloride(2365497-12-5 Free base)

 Apoptosis Apoptosis
ALK/ROS1 inhibitor 2e HCL 具有抗凋亡、抗增殖和抗肿瘤活性。
T62546 ALK5-IN-27

ALK5-IN-27 (Compound EX-04) 是一种 ALK-5 的有效抑制剂 (IC50≤10 nM)。ALK5-IN-27 对 ALK-2 也具有抑制作用。
T62393 ALK5-IN-25

ALK5-IN-25 (compound EX-02) 是一种 ALK-5 的有效抑制剂 (IC50<10 nM)，也能够抑制 ALK-2。ALK5-IN-25 能够用于研究癌症。
T62302 ALK5-IN-28

ALK5-IN-28 是一种 ALK-5 的选择性抑制剂，其 IC50≤10 nM，可以抑制 TGF-β 诱导的 SMAD 信号传导。ALK5-IN-28 具有抑制体内肿瘤生长的潜力。ALK5-IN-28 能够用于研究增殖性疾病（如癌症、纤维化疾病、系统性硬化症）。
T62116 ALK5-IN-33

ALK5-IN-33 (Compound EX-10) 是一种口服具有活性的、选择性的 ALK-5 抑制剂 (IC50≤10 nM)。
T62117 ALK5-IN-34

ALK5-IN-34 是一种选择性的、口服具有活力的激活素受体样激酶 (ALK) 抑制剂。ALK5-IN-34 能够抑制激活素受体样激酶的活性 (IC50≤10 nM)，也能够抑制肿瘤生长。ALK5-IN-34 能够用于研究癌症等增殖性疾病。
T79020 ALK2-IN-5

ALK2-IN-5为一种吡唑并嘧啶化合物，具有抑制ALK2及FGFR活性的作用。该抑制剂常用于癌症等疾病的研究，这些疾病与ALK2及/或FGFR的活性有关。
T62395 ALK5-IN-32

ALK5-IN-32 是一种 ALK-5 的选择性抑制剂 (10 nM<IC50<100 nM)，对 TGF-β 诱导的 SMAD 信号传导也具有抑制作用。ALK5-IN-31 具有抑制体内肿瘤生长的潜力。ALK5-IN-31 可用于研究增殖性疾病（如癌症、纤维化疾病、系统性硬化症）。
T62394 ALK5-IN-31

ALK5-IN-31 是一种 ALK-5 的选择性抑制剂 (IC50≤10 nM)，对 TGF-β 诱导的 SMAD 信号传导也具有抑制作用。ALK5-IN-31 具有抑制体内肿瘤生长的潜力。ALK5-IN-31 可用于研究增殖性疾病（如癌症、纤维化疾病、系统性硬化症）。
T62613 ALK5-IN-26

ALK5-IN-26 (EX-22) 是一种 ALK(Activin receptor-like kinase) 的抑制剂。ALK5-IN-26 对 ALK5 (IC50≤1 nM) 具有抑制作用。ALK5-IN-26 能够用于研究癌症。
T63114 ALK5-IN-7

ALK5-IN-7 是一种 ALK5 的有效抑制剂。转化生长因子 β (TGF-β) 是一种多功能细胞因子，能够利用细胞表面的复杂受体信号通路，通过自分泌、旁分泌和内分泌的方式参与调控细胞增殖、分化和凋亡。ALK5-IN-7 具有潜力进行 TGF-β 相关疾病和病症的研究（包括但不限于肿瘤、纤维化疾病、炎症性疾病、自身免疫性疾病等）。
T63498 ALK5-IN-6

ALK5-IN-6 是 ALK5 的有效抑制剂。 ALK5-IN-6 具有潜力进行 TGF-β 相关疾病和病症的研究，包括但不限于肿瘤、炎症性疾病、纤维化疾病、自身免疫性疾病等。其中转化生长因子 β (TGF-β) 是一种多功能细胞因子，通过细胞表面的复杂受体信号通路以自分泌、旁分泌和内分泌的方式参与调控细胞增殖、分化和凋亡。
T64051 ALK5-IN-9

ALK5-IN-9 是一种有效的、口服具有活力的 TGFβRI (ALK5) 抑制剂。ALK5-IN-9 能够抑制 ALK5 自磷酸化 (IC50: 25 nM) 并抑制 NIH3T3 细胞活性 (IC50: 74.6 nM)。ALK5-IN-9 具有良好的药代动力学特征，能够改善 hERG 抑制。ALK5-IN-9 对癌症疾病表现出研究潜能。
T61203 ALK5-IN-8

ALK5-IN-8 is a highly effective inhibitor of TGFβRI (ALK5). It hinders the phosphorylation of ALK5 on downstream signaling proteins (Smad2 or Smad3) by obstructing the interaction between TGFβRI and ligands. Consequently, it disrupts or prevents TGF-β signaling. ALK5-IN-8 shows promise in the study of diverse diseases associated with ALK5-mediated pathways[1].
T62614 ALK5-IN-29

ALK5-IN-29 是一种激活素受体样激酶 (ALK) 的选择性抑制剂。 ALK5-IN-29 对激活素受体样激酶的活性具有抑制作用 (IC50≤10 nM)。AALK5-IN-29 能够抑制肿瘤生长，可以用于研究癌症等增殖性疾病。
T62615 ALK5-IN-30

ALK5-IN-30 (EX-07) 是一种 ALK 的有效抑制剂，其对 ALK5 (IC50< 10 nM) 和 TGFβ-R1 (IC50< 10 nM) 具有抑制作用。
T3041 ALK inhibitor 2

FAK; ALK Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
ALK inhibitor 2 是嘧啶类 ALK 的有效抑制剂。它是一种睾丸特异性丝氨酸/苏氨酸激酶 2 (TSSK2;IC50=37 nM) 和粘着斑激酶 (FAK;IC50=5 nM) 抑制剂。
T3678 Entrectinib

RXDX-101,恩曲替尼,NMS-E628

 Trk receptor; ROS; ALK; Autophagy; ROS Kinase Angiogenesis; Autophagy; Immunology/Inflammation; Tyrosine Kinase/Adaptors
Entrectinib (RXDX-101) 是一种可口服的 Trk、ROS1和 ALK 抑制剂，具有抗肿瘤和中枢神经活性，抑制 TrkA、TrkB、TrkC、ROS1 和 ALK 的 IC50值分别为 1、3、5、12 和 7 nM。
T68537 CEP-14513

CEP-14513 is a potent ALK inhibitor. CEP-14513 displayed potent ALK inhibitory activity in both in vitro enzymatic assay (IC50 = 5 nM) and cell-based assays of ALK tyrosine phosphorylation (IC50 = 30 nM).
T61443 Trk-IN-7

Trk-IN-7 (compound I-6) is a highly potent inhibitor of TRK, exhibiting IC50 values ranging from 0.25-10 nM for TRKA, TRKB, and TRKC, respectively. In addition, Trk-IN-7 demonstrates notable inhibition against EML4-ALK (IC50 <15 nM), as well as ALK G1202R, ALK C1156Y, ALK R1275Q, ALK F1174L, ALK L1197M, and ALK G1269A (IC50 = 5-50 nM) [1].
T13139 TP-008

TGFβRI-IN-2

 Others Others
TGFβRI-IN-2 is a selective, potent and orally active inhibitor of (Activin-Like Kinase 5) ALK 5(pIC50 and pEC50 values of 7.6 and 6.63, respectively).

化合物

ALK-IN-5
Cat.No: T10283
Synonym:
Target: ALK
A 83-01
Cat.No: T3031
Synonym: ALK5 Inhibitor IV,A8301
Target: ALK, TGF-beta/Smad
ALK5 Inhibitor II (hydrochloride)
Cat.No: T22560
Synonym:
Target: Others
ALK/ROS1 inhibitor 2e HCL
Cat.No: T67699L
Synonym: (R)-1-(2-((2-methoxy-4-(piperazin-1-yl)phenyl)amino)pyridin-4-yl)-N-(4-(trifluoromethoxy)benzyl)piperidine-3-carboxamide hydrochloride(2365497-12-5 Free base)
Target: Apoptosis
ALK5-IN-27
Cat.No: T62546
Synonym:
Target:
ALK5-IN-25
Cat.No: T62393
Synonym:
Target:
ALK5-IN-28
Cat.No: T62302
Synonym:
Target:
ALK5-IN-33
Cat.No: T62116
Synonym:
Target:
ALK5-IN-34
Cat.No: T62117
Synonym:
Target:
ALK2-IN-5
Cat.No: T79020
Synonym:
Target:
ALK5-IN-32
Cat.No: T62395
Synonym:
Target:
ALK5-IN-31
Cat.No: T62394
Synonym:
Target:
ALK5-IN-26
Cat.No: T62613
Synonym:
Target:
ALK5-IN-7
Cat.No: T63114
Synonym:
Target:
ALK5-IN-6
Cat.No: T63498
Synonym:
Target:
ALK5-IN-9
Cat.No: T64051
Synonym:
Target:
ALK5-IN-8
Cat.No: T61203
Synonym:
Target:
ALK5-IN-29
Cat.No: T62614
Synonym:
Target:
ALK5-IN-30
Cat.No: T62615
Synonym:
Target:
ALK inhibitor 2
Cat.No: T3041
Synonym:
Target: FAK, ALK
Entrectinib
Cat.No: T3678
Synonym: RXDX-101,恩曲替尼,NMS-E628
Target: Trk receptor, ROS, ALK, Autophagy, ROS Kinase
CEP-14513
Cat.No: T68537
Synonym:
Target:
Trk-IN-7
Cat.No: T61443
Synonym:
Target:
TP-008
Cat.No: T13139
Synonym: TGFβRI-IN-2
Target: Others
Species：
Human (16)
Mouse (1)
Expression System：
HEK293 Cells (15)
Baculovirus Insect Cells (1)
E. coli (1)
Tag：
C-hFc (7)
C-His-Avi (2)
C-mFc-Avi (2)
C-His (1)
C-hFc-6xHis (1)
His (1)
His, GST (1)
His, hFc (1)
N-6xHis (1)
Cat. No. Product Name Species Expression System
TMPY-05771 ALK-5 Protein, Human, Recombinant (hFc)

AAT5,SKR4,TGFR-1,LDS1,transforming growth factor, b...

 Human HEK293 Cells
ALK-5 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 36.87 kDa and the accession number is P36897-1.
TMPY-01358 ALK-5 Protein, Human, Recombinant (His & hFc)

tβR-I,ALK5,AAT5,TGFR-1,LDS2A,LDS1...

 Human HEK293 Cells
ALK-5 Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 38.1 kDa and the accession number is P36897-1.
TMPK-00305 TGFBR1 Protein, Human, Recombinant (mFc & Avi)

tbetaR-I,TGFβRI,TGFbetaRI,LDS2A,ALK-5,TGF-...

 Human HEK293 Cells
transforming growth factor beta receptor 1 (TGFBR1), a key stimulator of tumor proliferation and metastasis, was a direct target of miR‑98‑5p. miR‑98‑5p overexpression resulted in the downregulation of TGFBR1 and the suppression of the viability, proliferation, migration and invasion of A549 and H1299 cells. TGFBR1 Protein, Human, Recombinant (mFc & Avi) is expressed in HEK293 mammalian cells with C-mFc-Avi tag. The predicted molecular weight is 38.2 kDa and the accession number is P36897-1.
TMPY-04366 ALK-5 Protein, Human, Recombinant (aa 200-503, His & GST)

LDS1,ALK-5,LDS2A,AAT5,SKR4,transf...

 Human Baculovirus Insect Cells
ALK-5 Protein, Human, Recombinant (aa 200-503, His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 62.6 kDa and the accession number is P36897-1.
TMPJ-01178 TGFBR1 Protein, Mouse, Recombinant (hFc)

ALK-5,ALK-5ALK<...

 Mouse HEK293 Cells
TGF-beta RI, also called ALK-5, is an approximately 55 kDa type I transmembrane serine/threonine receptor kinase. In the presence of TGF-beta, TGF-beta RI forms a complex with, and is phosphorylated by, TGF-beta RII. Phosphorylated TGF-beta RI can then transiently bind and phosphorylate Smad2 and Smad3. TGF-beta functions as a tumor suppressor by inhibiting the cell cycle in the G1 phase. Administration of TGF-beta is able to protect against mammary tumor development in transgenic mouse models i...
TMPK-00306 TGFBR1 Protein, Human, Recombinant (mFc & Avi), Biotinylated

TGFbetaRI,TGFBR1,ALK-5,SKR4,LDS2A,TGFB1R1,...

 Human HEK293 Cells
transforming growth factor beta receptor 1 (TGFBR1), a key stimulator of tumor proliferation and metastasis, was a direct target of miR‑98‑5p. miR‑98‑5p overexpression resulted in the downregulation of TGFBR1 and the suppression of the viability, proliferation, migration and invasion of A549 and H1299 cells. TGFBR1 Protein, Human, Recombinant (mFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-mFc-Avi tag. The predicted molecular weight is 38.2 kDa and the accession number is...
TMPY-05485 BMPR1A/ALK-3 Protein, Human, Recombinant (hFc)

ACVRLK3,SKR5,10q23del,CD292,bone morphogenetic prot...

 Human HEK293 Cells
BMPR1A/ALK-3 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 40.9 kDa and the accession number is P36894.
TMPY-01764 BMPR1A/ALK-3 Protein, Human, Recombinant (His)

bone morphogenetic protein receptor, type IA,ALK3,A...

 Human HEK293 Cells
BMPR1A/ALK-3 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 15.7 kDa and the accession number is P36894.
TMPJ-00325 BMPR1A/ALK-3 Protein, Human, Recombinant (hFc & His)

BMP Type-1A Receptor,Bone Morphogenetic Protein Receptor Typ...

 Human HEK293 Cells
Bone Morphogenetic Protein Receptor Type-1A (BMPR1A) belongs to the TKL Ser/Thr protein kinase family and TGFB receptor subfamily, including the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. BMPR1A is a single-pass type I membrane protein and highly expressed in skeletal muscle. BMPR1A contains one GS domain and one protein protein kinase domain. BMPR1A is necessary for the extracellular matrix depostition by osteoblasts. BMPR1A can activate SMAD transcriptional regulators, ...
TMPY-05308 CD45 Protein, Human, Recombinant (aa 1-529, His)

GP180,B220,L-CA,protein tyrosine phosphatase, receptor type,...

 Human HEK293 Cells
CD45 Protein, Human, Recombinant (aa 1-529, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 57.4 kDa and the accession number is P08575-5.
TMPY-05387 SLAMF7 Protein, Human, Recombinant (hFc)

SLAM family member 7,19A,SLAM7,CS1,CD319,CRACC

 Human HEK293 Cells
SLAMF7 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 49.1 kDa and the accession number is Q9NQ25-5.
TMPY-04318 GRIK2 Protein, Human, Recombinant (hFc)

GLUR6,EAA4,MRT6,GLR6,glutamate receptor, ionotropic, kainate...

 Human HEK293 Cells
GRIK2 (Glutamate Ionotropic Receptor Kainate Type Subunit 2, also known as GluR6) is a Protein Coding gene. The GRIK2 (one of the kainate receptors) gene resides in a genetic linkage region (6q21) associated with bipolar disorder (BPD). The gene coding for GRIK2 has been suggested as a candidate gene for autism based on its localization in the autism-specific region on chromosome 6q21 and the involvement of receptor protein in cognitive functions like learning and memory. GRIK2 belongs to the gl...
TMPY-05547 SLAMF7 Protein, Human, Recombinant (hFc), Biotinylated

CS1,SLAM7,CD319,SLAM family member 7,CRACC,19A

 Human HEK293 Cells
SLAMF7 Protein, Human, Recombinant (hFc), Biotinylated is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 49.1 kDa and the accession number is Q9NQ25-5.
TMPJ-00854 ETS1 Protein, Human, Recombinant (His)

V-ets Erythroblastosis Virus E26 Oncogene Homolog 1 (Avian),...

 Human E. coli
ETS1 Protein (ETS1) is a nuclear protein that belongs to the ETS family. Members of this family recognize the core consensus DNA sequence GGAA/T in target genes. Proteins function either as transcriptional activators or repressors of numerous genes. They are involved in stem cell development, cell senescence and death, and tumorigenesis. ETS1 is a transcription factor, containing one ETS DNA-binding domain and one PNT (pointed) domain. it has been shown to interact with TTRAP, UBE2I and Death As...
TMPY-05498 SR-BI/SCARB1 Protein, Human, Recombinant (hFc)

HDLQTL6,SR-BI,SRB1,CD36L1,CLA-1,CLA1,scavenger receptor clas...

 Human HEK293 Cells
SR-BI/SCARB1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 73.4 kDa and the accession number is Q8WTV0-5.
TMPK-01357 SIRP alpha V5 Protein, Human, Recombinant (His & Avi)

MFR,PTPNS1,P84,BIT,MYD-1,MYD1,SHPS-1,SIRPA,SIRP α,SIRP α V

Human HEK293 Cells
Signal regulatory protein α (SIRPα) is a regulatory membrane glycoprotein from SIRP family expressed mainly by myeloid cells and also by stem cells or neurons.SIRPα acts as inhibitory receptor and interacts with a broadly expressed transmembrane protein CD47 also called the "don´t eat me" signal.
TMPK-01363 SIRP alpha V5 Protein, Human, Recombinant (His & Avi), Biotinylated

SIRP alpha,MFR,PTPNS1,SIRP α V5,P84,SHPS-1,BIT,CD17...

 Human HEK293 Cells
Signal regulatory protein α (SIRPα) is a regulatory membrane glycoprotein from SIRP family expressed mainly by myeloid cells and also by stem cells or neurons.SIRPα acts as inhibitory receptor and interacts with a broadly expressed transmembrane protein CD47 also called the "don´t eat me" signal.Cancer cells highly expressed CD47 that activate SIRP α and inhibit macrophage-mediated destruction. SIRP alpha V5 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian c...

重组蛋白

ALK-5 Protein, Human, Recombinant (hFc)
Cat.No: TMPY-05771
Species: Human
Expression System: HEK293 Cells
ALK-5 Protein, Human, Recombinant (His & hFc)
Cat.No: TMPY-01358
Species: Human
Expression System: HEK293 Cells
TGFBR1 Protein, Human, Recombinant (mFc & Avi)
Cat.No: TMPK-00305
Species: Human
Expression System: HEK293 Cells
ALK-5 Protein, Human, Recombinant (aa 200-503, His & GST)
Cat.No: TMPY-04366
Species: Human
Expression System: Baculovirus Insect Cells
TGFBR1 Protein, Mouse, Recombinant (hFc)
Cat.No: TMPJ-01178
Species: Mouse
Expression System: HEK293 Cells
TGFBR1 Protein, Human, Recombinant (mFc & Avi), Biotinylated
Cat.No: TMPK-00306
Species: Human
Expression System: HEK293 Cells
BMPR1A/ALK-3 Protein, Human, Recombinant (hFc)
Cat.No: TMPY-05485
Species: Human
Expression System: HEK293 Cells
BMPR1A/ALK-3 Protein, Human, Recombinant (His)
Cat.No: TMPY-01764
Species: Human
Expression System: HEK293 Cells
BMPR1A/ALK-3 Protein, Human, Recombinant (hFc & His)
Cat.No: TMPJ-00325
Species: Human
Expression System: HEK293 Cells
CD45 Protein, Human, Recombinant (aa 1-529, His)
Cat.No: TMPY-05308
Species: Human
Expression System: HEK293 Cells
SLAMF7 Protein, Human, Recombinant (hFc)
Cat.No: TMPY-05387
Species: Human
Expression System: HEK293 Cells
GRIK2 Protein, Human, Recombinant (hFc)
Cat.No: TMPY-04318
Species: Human
Expression System: HEK293 Cells
SLAMF7 Protein, Human, Recombinant (hFc), Biotinylated
Cat.No: TMPY-05547
Species: Human
Expression System: HEK293 Cells
ETS1 Protein, Human, Recombinant (His)
Cat.No: TMPJ-00854
Species: Human
Expression System: E. coli
SR-BI/SCARB1 Protein, Human, Recombinant (hFc)
Cat.No: TMPY-05498
Species: Human
Expression System: HEK293 Cells
SIRP alpha V5 Protein, Human, Recombinant (His & Avi)
Cat.No: TMPK-01357
Species: Human
Expression System: HEK293 Cells
SIRP alpha V5 Protein, Human, Recombinant (His & Avi), Biotinylated
Cat.No: TMPK-01363
Species: Human
Expression System: HEK293 Cells
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